Circulating anti-PLA2R autoantibodies to monitor immunological activity in membranous nephropathy.
نویسندگان
چکیده
منابع مشابه
Recurrent membranous nephropathy in an allograft caused by IgG3κ targeting the PLA2 receptor.
Up to 80% of patients with idiopathic membranous nephropathy have non-complement-fixing IgG4 autoantibodies to the phospholipase A2 receptor (PLA2R). Membranous nephropathy recurs in approximately 40% of patients after kidney transplantation, but the mechanism is unknown. Here, we describe a patient with recurrent membranous nephropathy 13 days after kidney transplantation whose graft biopsy sp...
متن کاملAnti-PLA2R Antibodies in Chinese Patients with Membranous Nephropathy
BACKROUND ~This study used two standardized methods to evaluate anti-PLA2R antibody in serum of primary membranous nephropathy (PMN) among Chinese patients to determine Anti-PLA2R antibody distribution and whether immunological reactivity reflected by antibody titer correlates with kidney function parameters. MATERIAL AND METHOD ~Overall, 82 subjects with biopsy-proven primary membranous nephr...
متن کاملAnti-phospholipase A2 receptor antibody in membranous nephropathy; an Indian experience
Implication for health policy/practice/research/medical education: In an observational study,a group of patients with membranous nephropathy showed correlation of anti-PLA2R antibodies with disease activity and presence of primary MN. Please cite this paper as: Yachha M, Sharma RK, Mehrotra S, Prasad N, Gupta A, Kaul A, Bhadauria DS. Anti-phospholipase A2 receptor antibody in membranous nephrop...
متن کاملInteraction between PLA2R1 and HLA-DQA1 variants associates with anti-PLA2R antibodies and membranous nephropathy.
Risk alleles at genome loci containing phospholipase A2 receptor 1 (PLA2R1) and HLA-DQA1 closely associate with idiopathic membranous nephropathy (IMN) in the European population, but it is unknown whether a similar association exists in the Chinese population and whether high-risk alleles promote the development of anti-PLA2R antibodies. Here, we genotyped 2132 Chinese individuals, including 1...
متن کاملAnti-Phospholipase A2 Receptor Autoantibody: A New Biomarker for Primary Membranous Nephropathy
Primary membranous nephropathy (also known as idiopathic membranous nephropathy, IMN) is an organ specific autoimmune kidney disease characterized by the development of immune complex deposits in the sub-epithelial spaces, podocyte effacement and glomerular capillary wall thickening in the later stages. Clinical studies have demonstrated that over 70% of patients with IMN possess circulating au...
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عنوان ژورنال:
- Journal of the American Society of Nephrology : JASN
دوره 22 8 شماره
صفحات -
تاریخ انتشار 2011